Im gonna assume that it will work with a usb to ps/2 adapter tho im not 100% sure. You do have to use a ps/2 solution to program though. I just got mine yesterday and it will not program with a wireless. Just a note as well. The thing comes pre programmed so you will need to reprogram every button on it otherwise its preprogrammed with a bunch of the keys you will already be using. For example I used ctrl 1- ctrl 0, alt 1- alt 0,
ctrl num1 - ctrl num0, alt num1 - alt num0, and then same with he f keys and shit + key for the rest I believe. Anyway post back if ya have issues. Someone else pointed me in the right direction and id be glad to do the same if ya need it