I just picked this up yesterday and have been playing it with AoC.

I agree about the keys, but I went to using the thumb directional pad to strafe left/right, backup, and jump. I use the thumb button (the one above the thumb pad) for vent, and then the finger buttons are all used for bound keys for casting spells, doing combos, etc.

It took me a while, but I got rather comfortable with it and am really starting to like it.