now.. the wording is a bit unusual.. (seems like you are asking to flip the order of the keys... but i doubt that)

so... assuming you mean:
"can keyclone allow me to hit '=' to have all my characters do the assist macro.. then '2' to fire the fireball?"

the answer is yes. that is its primary job.

all the windows you ask it to manage will receive any key you hit in any one of the windows (there are varying details here.. do-not-pass & round-robin lists.. keymaps.. mouse-maps... but that's beyond the basics)

so.. run 3 wows... click on one of them... hit '=' .. see /assist happen on the other 2.. hit '2' .. and watch the cute little bunny get toasted
(bunny-nuggets!)

of course.. there are better ways to do this.. using focus and [target=focustarget] instead of powers directly from the spellbook... but i think you get the idea

if you have any other questions, please feel free to drop me a note.