I've also been having this problem. i have one vista (4 clones) and one Xp machine. they both tend to lock up at least once every 2 hours, with the Xp machine sometimes going a little crazy on me and locking up as soon as i maximise WoW again :S
all v 1.8i
for your ports issue, could it be that if you were to go into taskmanager you would see a few Keyclone.exe things running? might be making it more unstable with every new one you open too :S shouldn't require a whole system reboot tho.

I'll try this shift thing out later.. If it is that, I dunno what I'm going to do :P I abuse the shift key no end.

going to try this overlay reminder thing too