I only Dual box (so far) and I've got the q6600, OC'd to 3.3ghz, 8gb ram, a raptor drive, and an 8800GT 512, and I run 1 37" screen at 1920*1080 and a 17" screen at 1280*1024 and get between 60-100fps in each. What resolution is your monitor? I have a 24 at work and it's "only" 1920*1200, which is not much more than 1920*1080. I bet you will be just fine on the video card and ram side, but the CPU will be the deciding factor. My computer is mostly idle even when playing 2 instances of wow. I bet you can run 5 instances pretty well with that setup. You might have to turn off some eye candy on all but the main character, but I think you'll be just fine.