I'm 5 boxing and my tradeskills are as follows

Mining
Alchemy

Skinning
Alchemy

Enchanting
Alchemy

Leatherworking
Alchemy

Jewelcrafting
Alchemy

All transmute mastery. Also for those that do go transmute mastery, go do potion mastery first then switch to transmute.
It takes 1 Botanica run and 150g per, but its far cheaper than 4 primal mights.
4x Might per transmute mastery, 5x alchemists, 20x primal mights. Little bit expensive.

Also the new alchemist stones are ridiculously good.