I have level 60's

Paladin (tank)
Priest(Healing)
Mage(DPS)
Warlock(DPS)

So far it hasnt been to bad. I havent really tried PVP, but in PVE I have found the only thing I really have problems with is CC. I can AoE like a champ Hellfire+Arcane Explosion+Concecrate+Circle of Healing==pwnage. I too have found you need to match similiar abilities. For example i have a DOT button, so on the Lock and Priest I have a macro that runs through my dots. Then I have "bolt blast" button that casts Fireball, Shadowbolt and Smite at the same time. For me its been very fun so far. I would also like to try a Pally and 4xMages and a Pally and 4xShammans