Actually I've had just the opposite - when I moved to Vista, Mutlibox was very unstable so I tried out Synergy and it hasn't missed a beat since.

With the congifuration for Synergy, I found that if I had to make changes to it, it usually meant quitting and restarting the application. But I only had to do this initially while setting up my monitor array.

The only other thing is that when you shut it down under Vista, you get a message saying "the application is stopped working" (no shit! ).

Cheers,
Stealthy