My n52 took a few days to get use to. Had to sit down and figure out a logical programming scheme so at least it'd make sence to me what I'm pushing. I don't use the Dpad for moving, I changed it to "shift" for modifier macros. The 3 buttons in the center of the 14 I made my "a.s.d." row with shift+s being "w./forward" key... so it felt a lot like the WASD, with buttons all around it. Any out-of-combat spells (buffs/drinks/etc) or rarely used spells I still have bound to my keyboard (F1-F12 & such); but for combat stuff I found the n52 has enough buttons for the criticals spells/macros. I am still tempted to upgrade to a XKeys tho for more buttons.