Ctrl key modifiers do work with keyclone, I've been using them for at least 2 weeks. Haven't played around with alt or shift yet on the newer releases.

Look for a mod called Automaton. It auto repairs at a vendor, auto accept summons, group invites, rez, etc. Even skips quest gossip and accepts the next quest. You have to configure it to do these things of course, and I use Deuce Commander to make that a snap.

There is another mod for auto quest acceptance once someone shares. I can't remember the name, will have to look it up when I get back from work.