I've used the N52 for about 4 years now, I don't know how people play WoW without it. It might take some time to get used to, but it is definitely worth the effort. I don't use the thumbpad for movement by the way, I use the middle keys of the N52 for movement, just like you do on a keyboard. I have shift and ctrl bound to two of the thumbad buttons, once you memorize what all of your keys do (with shift and ctrl too), you'll be lighting fast.