Think of XKeys as additional keys rather than a macro environment. yes you can pass a sequence of keystrokes on a single button press but this is borderline botting (I know Blue have said it is ok but most of us still don't trust it )

So you bind an Skyes button to CTRL-ALT-F3 or similar and use Trinity (unlimited macros) to have a macro button bound to CTRL-ALT-F3 this macro would look like this

Code:
#showtoolip
/cast Totemic Call
or you could leave it as a spell button by simply dropping the spell onto the button bar.