I'm just a dual boxer, but I use the N52 for my secondary quite successfully. I will say though that I haven't been very happy with how hard it is to press the orange button or the (space) button which I use for TAB. Anyone else experience this or do I just have a bum controller?

Also of note, I run my second box (WoW) on Debian with WINE 0.9.30 and I found some open source drivers and a daemon for the N52 on that. Works great!