I'm using two PC's to play three characters. Each PC has an N52 attached. On one computer I play a single character that I refer to as my "main" character and on the other computer I play two characters that I call my "support team". Currently the support team is a mage and a priest. The N52 for the support team is programmed to switch between the mage and priest screens when sending commands.

I'll have to investigate some of the other software and hardware methods I'm reading about on this site to see if I find something I like better -- or combine it with my N52's.