I run 5 on one computer. In windowed mode I just click between them. When I started I was only running 3 with no software help, but now I use AHK to broadcast keys to all of them.

I put my main in the top left, one top right, and 3 on the bottom.

If I was just going to use 2 I would put them in windowed in opposite corners and just click between them to switch screens. I wouldn't bother with AHK/Keyclone unless I already had it set up or I wanted to pvp.