omg I have the same issue with the scroll wheel, it bugs the crap out of me! I'll be in a heated battle and the scroll wheel locks up causing me to lean over mid fight and unplug it.
I found out the cause, was due to scrolling too fast, if you scroll only once or twice it should be fine but if you scroll like it's a mouse it stops working.

I also enjoy them quite a bit, it has just enough buttons for me, and if I need more I find a way to micro manage what I currently have laid out so that I am being as efficient as possible.