For those who were around before ISBoxer, multiboxing today feels pretty similar.

I feel like we're back to this being a rather niche playstyle - certainly fewer of us today than there at this point last year. There's not as much activity on these forums, but there's multiple multiboxer discord servers that are still hopping. ISBoxer Discord: https://discord.gg/CRrJ8UGZG9; WoW Open Box Discord: https://discord.gg/gtsEc4rTCw

There are lots of options, but there doesn't seem to be any universally agreed upon solution - lot of people doing lots of different solutions as nodoze spelled out above. To be clear, none of them have all the same power and low barrier to entry that ISBoxer had. We're kinda back to the "let me see if I can make this work" sort of solutions. Not that the different tools are user unfriendly (WoW Open Box seems particularly well written that you can pretty much just figure it out in less than an hour), but we are back to the days of using a combination of software or hardware as well as lots of in-game macros and addons to make it all work together. Some comps that used to work pretty well in ISBoxer are probably less optimal with the different sorts of play styles now. I think we're all still learning a lot.