I'm sure that we won't reach a consensus on a single best setup. (Except that it's mine, of course :P) What would you like to improve about yours?

One dark-horse for managing the leader / clone thing is this:
Using action bar pages to free focus.

It's a little more complicated to set up than a focus-based system, but once you get it going you get all of the benefits plus you can keep focus free for CC or healing.