My systems are in between yours physical dimension-wise. All of mine are older pre-Ryzen 4core AMD APUs in mini-ATX Motherboards with ~256GB SSDs with no Discrete Graphic cards and are fine for WoW. Mine are all running 16GB but would be fine at 8GB for WoW.
In my case until recently those 4 boxes were for upto 4 of my kids to play on with each mirroring their screen to a quadrant in my 4-input Dell monitor so that isn't really multiboxing but would have been fine if I had been multiboxing on all of them so I think you both have a good chance of being successful with those setups.
If possible even in a hardware broadcast/multicast setup, I would do your keybinds without multicasting 1 of your actions to actually do something in more than 1 wow client at a time. Even if you do use a synchronous USB for your DPS clients (or even all 5 of your clients) you can still eliminate 1 of your keystrokes causing simultaneous action in more than 1 wow client by keybinding different keys in each wow client... In that approach if you press 3 keys to do Arcane Explosion in 3 mages you are still only doing 1 keypress per AE because for each key pressed 2 mages ignore unbound keys sent to them...
For example on the Koolerton, if you had 3 white keys in a row set to send 1 2 and 3 respectively you would in your 3 mages the following keybinds:
-Mage 1: Keybind 1 to FrostBolt and unbind keys 2 & 3;
-Mage 2: Keybind 2 to FrostBolt and unbind keys 1 & 3;
-Mage 3: Keybind 3 to FrostBolt and unbind keys 1 & 2;
If you do that you are hopefully future proofing your setups and in keeping with both the letter of the law and the spirit of the law... That hopefully will help keep us from all having to buy FrankenBoards (TM).
With the above approach technically a single Koolertron could easily have enough keys to do all your main needs and be always multicasting via the syncronous USB to all 5 WoW clients with no single keypress causing more than 1 action in 1 wow client at a time.
With this Koolertron there are plenty of keys and even a 4MP could easily have 4 Keys set up for each main spell with plenty to spare. If you want to do them to cast pretty much at the same time then press the 4 keys... If you want to Round Robin something then press them in sequence in the row.
Very straight forward to organize and the keys could even be color codes and/or labeled with icons if desired:
https://smile.amazon.com/gp/product/B076LRJ528
In the end I suspect enough people will multicast and even the above may not be allowed and we may be forced to use certified compliant FrakenBoards (TM).
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