Thanks for sharing. Your system is really good and it definitely allows you more flexibility in being able to keep up with what's going on, on your screen and dealing with unexpected mechanics, whereas I often times find myself choosing between healing and avoiding mechanics.
That being said, the only drawback to this style is that you REALLY need to be able to line up your characters with your focus macros and be very precise on your targeting. Your naming convention is so good for this. Outside of that, the only other way to really accomplish this would really be through time and the learning curve of adjusting to the playstyle and pure muscle memory for when to do what. I'm definitely not really willing to put in the time to adjust to the system today, but I will probably look to move to a system like this in SL.
One other thing I've toyed with is using a clickbar to set focus using a /focus mouseover macro. It doesn't free up your mouse so I'm not sure how useful that really is, but it does eliminate the need to sit there and click spam when you're trying to deal with other things.
Lastly, I really like how old school your setup is. Straight key broadcasts and in game macros. Reminds me of using keyclone once upon a time. It's really not all about the ISBoxer setup but really managing the playstyle and getting good at it.
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