Yes, and not only that: ISBoxer enables you to send multiple keypresses and therefore multiple macros
E.g. for warlocks you could send (order is important)
shift-ctrl-alt-1 /castsequence reset=target Curse of Shadow, null
shift-ctrl-alt-2 /castsequence reset=target Corruption, null
shift-ctrl-alt-3 /cast Shadow Bolt
shift-ctrl-alt-4 /cast Life Tap
shift-ctrl-alt-5 /cast [combat] !Shoot
Warlock will apply debuffs and SB until mana empty, then life tap until health empty, otherwise wand.
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