I send multiple actions at once, most are macros defined in ISBoxer so that I can keep my toon's action bars clean for solo play.

For Warrior
button 1 "pull" (other toons do nothing): battle stance | charge | overpower | castsequence of battle shout, demo shout, thunderclap
button 2 "single target": defensive stance, equip 1-hand and shield | bloodrage | shield slam | revenge | shield block | sunder armor
button 3 "aoe": berserker stance, equip 2-hander | berserker rage | castsequence of whirlwind, cleave | execute

For Druid
button 1 "pull" (other toons do nothing): dire bear form | feral charge | faerie fire | demo roar
button 2 "single target": dire bear form | maul | faerie fire
button 3 "aoe": dire bear form | faerie fire | swipe

Also liberal use of /startattack in macros to ensure white hits even when abilities are on cooldown or lacking rage, but watch out with charge because warrior can't be in combat, so /startattack breaks charge.