some people put a 2x2 setup on a 2nd monitor with their main on the primary display... and odds are, your graphics card support dual monitors.

my suggestion, find an old monitor and go for it. try to keep your aspect ratios the same

to figure your aspect ratio:

get res of main monitor... keep it sort of low.. helps gpu/bus rates... so 1600x1200

aspect ratio: 1600/1200 == 1.3333

on the other monitor, if you do a 2x2 (the default size of a region is 1/4 screen res... making a 2x2 easy).. then each region would be 800x600, aspect ratio 1.333 as well.

BTW.. PiP will still work in this configuration...

whatever you come up with.. please post a screenshot (or pic of your rig) to the screenshots section (hardware specs as well please.. helps when others try to figure out what they want to do)