Hmm, problem with one screen set up is when I switch, my UI is too damn tiny to be useful. Making clicking and targeting a real pain. If I could get the PiP to work it might be worth it but wow loads the above screen in wide screen and the below three in 4:3. Even tho the resolutions are in order.

1680x700 loads as widescreen.
560x350 loads as normal.
Same for the other set up though, 1050x560 loads as normal too.

=(

Maybe I should get 4 monitors, but that would be a shame since I use a rather good asus en8800 ultra. -_- And a second pc is a bit overkill to overcome this one problem for me...

But I agree the first set up feels much more convenient, it has a much nicer playstyle and doesn't hurt my neck. Just that at the rare times a rogue pops on my main and kills it. Or my main dies in any situation. I mess up so much on switching because I can't click reliably at all. xD