If I understand your question the answer is yes but it isn't as many setups as it sounds...
I may not explain it fully properly with the correct terms but conceptually you just setup each VFX source once on each client and then you kinda "subscribe" to them on the others. Note that you determine whether each source is "view only" or interactive when you subscribe to it... You can also magnify or shrink the display when you subscribe...
What I would do, in hindsight, is setup all my sources on each of my background clients first and then go to my main Foreground client that I typically drive from and "subscribe" to each of those background sources...
Make sure you set them to be part of the auto load group (or setup a custom group if you want).
Once you have your main/lead client working the way you want and everything saved you can then either go and setup each other client individually (which is what I initially did) or you can try to leverage the auto-sync feature which will essentially copy the "subscription setups" to all the background clients (minus the ones that they are the source for). The auto-sync feature is pretty smart and works pretty well. After doing everything manually I later accidentally used it and liked the outcome and things would have likely been easier had I just done that from the beginning (in hindsight)...
Note that at one point I had to reinstall everything because I had played with the permissions on the warcraft files confusing the blizzard patcher and kinda corrupting my install... I also had to redo my location for my sources/destination when I switched to ElvUI and then again had to redo once I started getting LUA errors in ElvUI and switched back. The auto group and auto-sync features really helped speed up things...
Note that I did sometimes have issues with losing my setups and having to redo them which was a little annoying but thankfully they are pretty easy to do... I am also not exactly sure what makes the setups 100% fully persistent any my assumption so far is that there isn't any bugs and that it was me doing something incorrectly. I recommend being very diligent on making sure any source and subscription are in the "auto group" and saved and after any major change and I started logging fully out of my WoW clients and starting everything fresh to make sure things were persistent. I can now do that all pretty fast so I just do it to be safe and make sure I am not surprised later.
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