If you have fully working addons which facilitate multiboxing and auto-accept/turn-in of quests I don't see multiboxing slowing you down much as any slows would be somewhat offset by faster kills.
I think the idea scenario would be same race, ideally same class, groups that have fast movement and some self healing... Hunters are great as they have fast movement via "aspect of the cheater" and with their pets they are basically their own "Trinity" being their own mini tank, healer, & DPS... Druids are also great as their cat form can get fast movement (in addition to their actual travel form) and their healing resource (mana) can regen while leveraging a different resource (energy) for killing which lessens needs to drink between fights (even when healing yourself). Shaman also have fast movement and self-healing but the same resource is used for damage/healing/fast-form so drinking may be more of a thing...
Having multiple characters should speed up kills and add minimal overhead to quests (with the right addons) and if the exact same race/class they would all have the same quests (& could maybe leverage broadcasting at times as well)...
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