I think most of us use key binds for DPS and tanking rotations and click heal via addons to control healing. The amount of hotkeys you'd need to manage 5+ keybinds for each healing spell you want to use (not to mention spell ranks in classic) would get obnoxious if you tried to bind all of them.
I like ElvUI with Clique myself. ElvUI is great for being able to easily manage things like sorting raid frames by name and importing your UI layout pixel perfectly across all of your characters so you can click heal effectively. For example, with my paladin I use left click to holy light rank 4, right click to flash of light. Mouse wheel up to freedom, mouse wheel down to cleanse and so on. Then I have CTRL+Shift bound to one of the thumb buttons on my Naga mouse so I can use CTRL+Shift + left click and so on for the spells I use less often like DI or LoH.
It takes a while to get used to but it's a lot faster than trying to manage 20something keybinds. Then I have my single target DPS and tanking rotation on 1 and my AE rotation on 2 as ISBoxer keymaps to manage various castsequences and such. Debuffs like demoralizing shout I have on individual hotkeys since they need to be managed separately.
All in all I have around 6-8 actual hotkeys I press regularly during combat (plus mouse clicks) and then another dozen or so I use infrequently like my mount hotkey, hearthstone, etc. The idea is to do as much as possible with as few keys as possible. If you build a setup requiring dozens of key presses you're going to give yourself RSI.
MiRai actually has quite a few instructional videos on how to set up most of the useful ISBoxer features like repeater regions and such.
https://www.youtube.com/user/Multiboxology
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