Great post FrostBlayze. Enjoyed reading many similar experiences as I had.

Pretty much the first thing I added in my ISBoxer setup was a button to switch auto-IWT on and off, for the same reason as you: that all melee jumped into the lava in ragefire caverns

I understand your idea to have your healer's actions on ALT-keys and only when mouse is in the heal-frame, as you know from the other thread, I have similar. But does it mean you when you need to press ALT-3, that you can't dps because ALT is held down and your dps buttons are not mapped to ALT? If so, my suggestion is to move the main heal to a button that you can mash at the same time as your main dps button. I try to put ctrl/alt/shift keybinds on for the stuff that I only use sporadically. My weakness is still decursing, where my hand just can't twist easily to mash dps and the decurse button, and also I can't see the GCD of the decurser so often my whole team just stands around like idiots until the poison is gone. But ... dps+heal with round-robin-interrupt? Moorabi doesn't stand a chance!