Code:
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/use [@target,harm] Moonfire;[@mouseover,help] Rejuvenation
I find combining multiple offensive and defensive skills into a single keybind helps a lot.

Code:
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/castsequence reset=3/target Curse of Agony, Corruption, !Shoot,,,,,
It used to be possible to create a false cooldown with castsequences using commas that can help a lot in managing multiple DoT's. I'm not familiar with the new API so somebody else will have to confirm whether something similar is possible currently.