A good idea when asking these questions is to provide the steps you use to reproduce the "failure."

Something like this:

1. My alt follows my main up to a node.
2. My main stops just past the node.
3. My alt changes its view so that the node is in the same spot on the alt's screen as it is on the main.
4. Then I have a mapped key that does the following steps:
--> Click on the node with Main (which works OK)
--> Sync cursor on alt to put cursor over the node
--> Sends keystroke on the alt that is bound (in-game) to Interact with Mouseover <------ this step doesn't seem to work
5. Here's my config: http://isboxer.com/forum/viewtopic.php?t=13

http://p1.portal2sounds.com/154