Well, you don't technically need to set them up prior to actually getting ingame. If you had all the information as to what names you'll have and on what realm (if there are any) you could set everything up in advance. Or you could create a dummy team that you modify once you actually get your characters creater. You can also refresh all changes you make to the team to Innerspace and the ISBoxer addon without having to completely log out of the game.

Hotkeynet does not handle character names or anything of the sort as far as I know and all the relevant macro work needs to be made ingame so no real issue there, but of course means you can no set everything up in advance.