Assist macro only working from select slots across all teams

[Sumasaum]

I'm suspicious that my problem might be in the WoW Macro Sets in the Game Helpers sub menu. I'm attaching a snapshot here. Do all of these actions need an in game keybind? I unbound a lot of things in game I didn't want to risk interfering with ISBoxer. Assist Target, Focus Target, and Target Focus are all currently unbound in game although I don't remember when I did that. I also use the F1-F8 function keys as keybinds for the bottom left action bar, so all of the in game target party stuff was cleared too.