I guess it depends on ilvl. Most of the people smashing you in wPvP will try it when they have 40+ ilvls on you. If similar ilvl then you should beat 2 people easily.

Years ago my biggest issue on my trinity 5 box crew was my reaction speed. I played a prot war + resto shaman + 3 BM hunters. No matter what I did I would get smashed. I was then healing with grid and clique. My reaction time was abysmal.

I made an effort to stop click healing and got on the naga wagon. I setup a map to heal and well, the naga is gone so now I use the keypad on the keyboard.

SLOT 1 = 2
SLOT 2 = 1
SLOT 3 = 3
SLOT 4 = 0
SLOT 5 = .

I drive from the healer and I use grid and custom grid layouts to organize my grid units like my keypad. So the buttons are 1:1 with the characters I want to heal.

Nomod = Single Target heal rotation
Mod: ALT = Single Target hard heal rotation
Mod: SHIFT = AoE heal Target
Mod: ALT+ SHIFT = Dispel Target

I also mapped a survival keybind to the Mod: ALT binding. Basically if my shaman was healing a hunter, the hunter would get a healing surge and the hunter would disengage.

To escape the gank one shots setup a keybind and call it ALL WALL. This one should be obvious. One button to wall every character. This will save you from one of those big ganks other multiboxers will try to get you with, a bladestorm, ele shamans, etc.

I really liked resto shaman for the AoE healing. When stacked which is usually a big no-no in PvP a resto shaman can make a difference.

If you manage those two things your reaction time should be really good. Like John said the hunter toolkit is nice for PvP. You can even bind your traps to [@player] to drop them right at your feet, then disengage. So if the melee is really intent on getting a hunter they''ll get a trap for their trouble!