Unfortunately EQ2 is no where near as boxing friendly as wow... but... I find its PvE to be 10x more fun. You can find my guide to Keyclone in my signature specifically for EQ2 with pictures. Unfortunately as it stands it requires you to use innerspace, Rob(the Keyclone dev) is working on the lock forward feature and that shouldnt be an issue for much longer **crosses fingers**

As for macros... as far as I know there is no quest accept macro. The EQ2 multiboxing wiki is still pretty sparse, but I cover how I heal there, and keyboard layouts. Ill go ahead and repost here.

I take the f1 - f6 keys off of all my toons buy my healers. I then make a tertiary bar with macros that have /target Tdktemplar and /target tdkfury etc etc. I then make sure those bars are in order with my main tanks group window, as every group window appears differently to the viewer. This way I simply hit the F1 key to target my main tank, and any other key as the MT sees it for easy heal targeting.

I use insert, home, pageup, pagedown, and end for my healing.
I use num pad 1 - 7 for dps and 8 and 9 for target MT and /follow

Im just about to try the pvp server, so, that will force me to come up with a way to change leaders, and Im not looking forward to that... Ill definitely update the wiki once I find something that functions.

**Edit
Forgot classes, my current setup is
Guardian
Fury
Defiler
Conjuror
Illusionist
Wizard(or warlock)

We are still working on a PVP setup, but Ill only be 4 boxing there and playing with friends.