HO's... That is where my hotbar jacking came into play... again, this is all personal knowledge, your mileage may varry...

I determined you can go one of two ways. You can configure your hotbars and hotkeys, using Alt & Shift and Normal, to map every single ability, no macros. Then, paying very close attention to the HOs, you can execute them near perfectly as long as you have the classes to finish off the HO. The drawback, is you end up with 4 toons with random abilities strewn all throughout the keyboard.

When you're in a fight, especially in a dungeon, you are focused on keeping all your 'alts' in one spot, keeping the mobs in another spot, and keeping the tank on the other side of the first two. Then, you're focused on healing the tank, not overnuking with the wizard, and switching targets to keep aggro on the tank. If you push one wrong key at the wrong time, you will die (I need a t-shirt with that slogan). HO's are the last thing on your mind.

I tried to play the HO route as outlined above... Then I went to the original way (which i lay out above) where each key does the same thing across all toons. With this combination, if I want to stun a mob, I can keep him stunned by simply pushing #2 once every second. If I wanna drop a mob ASAP, I slam #4 once a second. I don't have to think, and not having to think helps alot when boxing.

In the 'lesser' fights, i'll sometimes pay attention to an HO and try to pull it off, but... In non-epic encounters, there's really no need to. The only fights that last long enough for an HO or two are the triple-ups... and usually you're too focused on the above stuff to worry about an HO.

Remember, you're monitoring multiple toons on multiple windows, each doin their own 'thing', if you will... For the first month or two, you'll have your hands full just keeping everyone alive. After that, whatever you discover, come back and let us know!

g'luck