"Not enough Memory" - crashes, freezes and more

[mbox_bob]

If you have replaced the GPU, you will need to create a new Window Layout in ISBoxer, as the device references will have changed and this can have a detrimental performance impact when Windows attempts to write to a device which is no longer there. Use the Window Layout Wizard, and create a New layout (don't choose one which says (existing)) from the drop down. If it is not the issue, you can always swap back to your old layout.

Either that or it is paging to disk a lot due to lack of ram, but then some basic monitoring would show up the lack of ram quite easily and it doesn't really gel with what you say about swapping graphics cards.

/e
heh, after re-reading your original post, I see you say you've tried a fresh profile. Well, that just makes it really weird then, and perhaps you should be getting a compatibility diagnostic instead. http://isboxer.com/wiki/Diagnostics