Its probably overkill but my solution was to make a copy of my WoW folder and rename it "World of Warcraft DB". When I want to play solo on my main I launch WoW from my old shortcut & when I want to run my triple box I launch it with Keyclone commands with Keyclone pointed at my second folder. This way I have a completely different set of addons and video configs for my multiboxing vs my main.