I ran a lot of vanguards. some ganks and some wormholes with this basic setup.

Primary screen
https://youtu.be/fVykdNib6g4

second screen (to my right)
https://youtu.be/mKU24mmlq6I

My booster and hacker/ore pilots were on the secondary machine which had a screen to my left.

Basically I only really used isboxer for window and cpu management. My videos were posted all over the official forums and CCP at the time had no issues with me while they were banning other people for using stuff like videofx and round robbin mouse clicks.