the old turbo boost uses a driver to control affinity (the one you mention) and the new one that doesn't (im assuming its now done by the os). implementation depends on the motherboard, and i can only speak for Gigabyte, but after a few weeks of use windows removed the Turbo boost program on its own and wont let you install it again. (typical microsoft)

i simply Couldn't assign affinity to processes anymore. this is not bad for regular users, you definitely want those boosted cores to run your game, not such a good id ea when you have multiple copies of the same software running in parallel.

i found a way of using "Legacy" mode with Turbo boost 3.0 (on the BIOS, and after upgrading it.) that makes the skylake processor work like a Broadwell,only then will windows allow me to install the Turbo boost drivers and disable the function. at least now windows wont mess with my affinity anymore. still, given that windows made this change unannounced and given that you don't get to choose what your OS will do anymore there's no telling what they will do next.

i don't recommend the Skylake series of processors if your main use case is multiboxing. in my case i use it for work and its a beast. so im still happy.

as far as IO, on the new hardware (x299) i have seen a noticeable increase in performance now that im running from two SSDs instead of the old setup with the same two SSDs on raid 0. almost no stutter in Dalaran and loading the ship i don't even have alts get bugged and fall through the floor anymore. lol