First, if you're changing your settings with the settings window already open, then the drop-downs and sliders don't reflect the changes made. If that's not the problem, then you'll need to be more specific.
Second, other than "MSAAQuality 1" (this isn't a valid value for that CVar), I see no issue with your macros, but you happen to be changing a bunch of settings at once. If you don't need to change all of those settings, then you should avoid doing that to save on performance.
Finally, if you're still getting weird performance then you could've easily changed something you shouldn't have by using old macros. If that's the case, then the only way to fix that would be to exit your game clients, delete your config.wtf files from the WTF folder, start the game without Inner Space, enter the game world, adjust your video settings if necessary, exit the game, export from ISBoxer, and then re-launch your Character Set.
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