I guess there's the potential problem where you won't be able to trade anything between those characters unless they share a connected realm,
I don't mind about the trading. One of them will be an enchanter so it can get any dungeon loot.

but, no, other than perhaps some edge case situations where you're hard-coding namelists into add-ons, which could probably be fixed anyway if you knew Lua well enough.
I know nothing about it except it's used for addons : D

Do you know anything about the issues with Jamba that ebony brought up?