As far as I know, the only way they do detect it is when people are streaming with such a setup and showing it off, as seen here.
I'm certainly no EVE expert and I'm not up-to-date with the latest complaints on CCP's forum, but I can tell you that there's plenty of people still using ISBoxer with it, even if you can't replicate keystrokes and mouse clicks. Lax even built a special launcher for EVE to support both ISBoxer users, and non-ISBoxer users. It seems a bit odd that he'd go through all the trouble to do that (and then maintain it), if he had no EVE customers left, since you can still launch EVE through ISBoxer even without his launcher.
Do not send me a PM if what you want to talk about isn't absolutely private.
Ask your questions on the forum where others can also benefit from the information.
Author of the almost unknown and heavily neglected blog: Multiboxology
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