First time melee team, need some help!

[Syferr]

Long shot and i didnt read everything here but make sure ISboxer addon is turned on all your alt accounts

[Ughmahedhurtz]

I presume you've also made sure that you have your followers assist your main before trying to IWT?

Perhaps if you shared your config, we could point out what's wrong with your config.

[JohnGabriel]

Also in WoW keybinds you need Interact with target set to E. You mentioned it works on your main so I assume you already did it on that toon at least.