I have ISBoxer setup to button mash in a descending order from = to 5. 1, 3, and 4 I manually press for interrupts, active mitigation, and horse mobility. The 2 key is my macro key for ISBoxer because I find it very easy to press while keeping my other fingers on Q and E for movement.

My priority is:
Avengers Shield
Judgement
Artifact ability
Consecration
Hammer
Light of Protector

I throw in Seraphim when it's talented and in some situations I take the Artifact ability off and use it manually. So I just smash the 2 key and everything dies and you end the fights at full hp. I have solo'd the last 20% of many heroic bosses when the rest of the group dies.