They aren't, but over the course of several years people have just migrated to ISBoxer because it's the software with the most features, and the most support going for it. Anyone is more than welcome to pick up any software they'd like, and then create guides/tutorials for it, sorta like what SaliusPlays was doing for some time with HotKeyNet before he... took a break from it, I guess.
That does seem like an odd limitation, but I was going to suggest that if your mouse software allows you to re-bind your mouse wheel to keyboard keys. Although, that might just create a new problem in game where you can no longer use your mousewheel because it's now assigned to keys on your keyboard.
However, since you now have ISBoxer, it certainly supports the mousewheel.
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