Personally, I wouldn't say that just a 4K screen is what allows you to keep track of things better, but a large 4K screen, or just a large screen in general. I played like this on a 23" 1080 display back in the day, where all of my clients were rendering at 960x540 placed in a quadrant layout, and they were small. If you had a 1440 display, then you could do 1280x720 in a quadrant instead, but unless your screen is big (30"+) then the game clients will still feel small.

Most 4K displays that are on the market today are ~27" (not talking about Korean panels on eBay), and that is not going to make the game clients feel any bigger than a similar sized 1080/1440 screen when using a quadrant layout, but if you have a nice large screen, like a large 1080 television or large 4K display, then I agree, a quadrant layout is very nice.