Same as bob, I see no reason why you'd be experiencing this behavior. However, you can clean up and remove, what seem like, unnecessary commands in your slot-swap macro:
1) You've got a typo (an added space) on terrainTextureLod in both of your macros.
2) You're shutting off MSAAQuality in the low macro, when it isn't enabled in the high macro.
3) Both macros have you disabling SSAO, which seems unnecessary if you aren't turning it on in the first place.
Also, render scale is a gigantic resource hog, and I would ask... Why are you using SSAA rather than MSAA for anti-aliasing? MSAA with Multisample Alpha Test is going to be much easier on your hardware than any level of SSAA will be. So, if you need anti-aliasing, then I'd recommend MSAA over SSAA any day of the week.
Finally, if your Key Maps are disabled and you're swapping around windows, then your settings aren't going to change based upon the way your profile is set up.
EDIT: To clarify, I mean that you should probably be setting render scale back to its default 1.0 value on the high macro, and using MSAA instead if you want any form of anti-aliasing.
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