I don't know if I understand this. What do you mean by groups? Do you mean Key Maps? Action Target Groups?
Normally, Variable Keystrokes are used very little in a game like WoW because we can use macros. It sounds as if you're using Variable Keystrokes to replace a Straight Key Broadcast, which is is the most basic part of ISBoxer (and any multiboxing setup, really). I don't have a good reason for why you shouldn't use Variable Keystrokes in this manner, other than it's probably going to make things more messy as you continue to add more because you'll have no way to categorize things (which is what Key Maps are used for).
If you haven't already, I'd suggest checking out my playlist for MMOs and ISBoxer. I'm guessing you know most of the basic basics, so you can probably start with part two and go from there. The descriptions of each video is filled with links to different videos and sections of the ISBoxer Wiki.
Honestly, there isn't much compatibility between users' profiles beyond the standard Wizard setup because everyone puts their own touch on their own profiles after that, and then trying to share it with someone else usually requires a lengthy explanation on how to use it and where to find everything.
If I gave you my profile and you saw this list of Key Maps, it'd either take you hours upon hours of attempting to decode things, or take me hours upon hours to write a 3500 word essay on what to do with it.
Don't mind that the font is a bit messed up in my profile since I moved to Windows 10.
It can be frustrating, but like you already said, it takes trial and error since there are several ways to do things. ISBoxer is a toolkit (hence, its name), and it's up to you to figure out how to use those tools. If you have questions, then you ask for help, and hopefully someone can help you find the answer.
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