Wouldn't it be quicker (and easier) to just shut down all the other applications that aren't necessary for multiboxing to see if freeing up memory fixes the issue? As Ugh already mentioned, Chrome eats up a ton of RAM, and it's running in the screenshot you posted.
WoW is going to eat up 2GB per game client, so five game clients is 10GB right off of the bat. Add in an additional 2-3GB for the OS, and you're quickly running out of memory for anything else to sit around idle in the background.
Lyonheart reported memory issues in the hardware forum (using 16GB) and someone else chimed in to say they had a memory leak. At least a few people have mentioned 16GB not being enough for them on the ISBoxer forum, as well. Also the Details tab of the Task Manager will tell you what is eating up memory, and how much it's eating up.
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