Hi there, I don't have any experience with PIP, but maybe I can help you with your second thing. I also use two monitors - one char on my main screen, and 4 on the second screen. Your Command would look like this:
Code:
<Command ResizeAndPosition>
    <SendPC Local>
        <SendWinM %1%>
            <SetWinRect 0 0 1600 900>              
        <SendWinM %2%>
            <SetWinRect 1600 0 640 512>
        <SendWinM %3%>
            <SetWinRect 2240 0 640 512>
        <SendWinM %4%>
            <SetWinRect 1600 512 640 512>
        <SendWinM %5%>
            <SetWinRect 2560 512 640 512>
Hope this helps!